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KMID : 0384120000200040367
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Korean Journal of Clinical Pathology
2000 Volume.20 No. 4 p.367 ~ p.371
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Comparison of c-erbB-2 Oncoprotein Expression in Serum and Tissue of Gastric Cancer Patients
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Kim Jin-Ju
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Abstract
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Background :
Methods : Serum c-erbB-2 levels of 67 gastric cancer patients were measured. In 27 patients, tissue levels of c-erbB-2 in paired normal and gastric cancer tissues were measured by ELISA (Triton Diagnostics Inc., USA).
Results : As 14 U/㎖ for positivity, the sero-positivity of the c-erbb-2 was 33% (22/67). The positivity showed no differences in cancer stages and tumor differentiations (well-moderate 29%, poorsignet ring cell type 35%). Tissue c-erbb-2 level were 390±284 U/㎖ and 568±536 U/㎖ in normal and cancer tissues, respectively. Blood c-erbB-2 levels did not correlate with either cancer tissue c-erbB-2 levels or normal tissue c-erbB-2 levels. Nineteen out of 27 patients showed higher c-erbB-2 levels in cancer than normal tissues. The positivity of c-erbB-2 in serum was 7 out of 19 c-erbB-2 positive cancer tissue, whereas the positivity in serum was one out of 8 c-erbB-2 negative cancer tissue.
Conclusions : Elevated blood c-erbB-2 oncoprotein level might reflect elevated c-erbB-2 level of gastric cancer tissue.
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KEYWORD
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Serum, Gastric cancer tissue, c-erbB-2, Gastric cancer,
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